Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.47 |
| ▸ | ITGAV | P06756 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL695420 | 0.94 | MAPT (0.54) | ALDH1A1KDM4ELMNAPOLBHPGD | |
| SCHEMBL688325 | 0.94 | ALDH1A1 (0.51) | ALDH1A1KDM4ELMNAPOLBHPGD | |
| SCHEMBL688224 | 0.93 | PTGER3 (0.51) | ALDH1A1KDM4ELMNAPOLBHPGD | |
| SCHEMBL688073 | 0.93 | ALDH1A1 (0.44) | ALDH1A1KDM4ELMNAPOLBHPGD | |
| SCHEMBL686731 | 0.93 | MAPT (0.55) | ALDH1A1KDM4ELMNAHPGDMAPT | |
| SCHEMBL4700630 | 0.92 | MAPT (0.44) | ALDH1A1KDM4ELMNAPOLBMAPT | |
| SCHEMBL686838 | 0.92 | PTGER3 (0.51) | ALDH1A1KDM4ELMNAPOLBHPGD | |
| SCHEMBL687428 | 0.91 | PTGER3 (0.56) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL687886 | 0.91 | PTGER3 (0.56) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL687518 | 0.91 | LMNA (0.46) | ALDH1A1KDM4ELMNAPOLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1176956-B1 | CARBOXYLIC ACID DERIVATIVES THAT INHIBIT THE BINDING OF INTEGRINS TO THEIR RECEPTORS | ENCYSIVE PHARMACEUTICALS INC (US) | 2008-01-09 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |