Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | FBP1 | P09467 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | BRS3 | P32247 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573341 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2KDM4EALDH1A1FBP1CYP1A2 | |
| SCHEMBL19567209 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2KDM4EALDH1A1FBP1CYP1A2 | |
| SCHEMBL951176 | 0.79 | ALDH1A1 (1.00) | SMN1; SMN2KDM4EALDH1A1FBP1CYP1A2 | |
| SCHEMBL676381 | 0.78 | SMN1; SMN2 (0.55) | SMN1; SMN2KDM4EALDH1A1FBP1CYP1A2 | |
| SCHEMBL4573347 | 0.78 | SMN1; SMN2 (0.55) | SMN1; SMN2KDM4EALDH1A1FBP1CYP1A2 | |
| SCHEMBL6869977 | 0.78 | SMN1; SMN2 (0.55) | SMN1; SMN2KDM4EALDH1A1FBP1CYP1A2 | |
| SCHEMBL696687 | 0.78 | SMN1; SMN2 (0.55) | SMN1; SMN2KDM4EALDH1A1FBP1CYP1A2 | |
| SCHEMBL6847934 | 0.78 | SMN1; SMN2 (0.55) | SMN1; SMN2KDM4EALDH1A1FBP1CYP1A2 | |
| SCHEMBL179126 | 0.78 | CYP1A2 (0.58) | SMN1; SMN2KDM4EALDH1A1FBP1CYP1A2 | |
| SCHEMBL17832900 | 0.77 | SMN1; SMN2 (0.54) | SMN1; SMN2KDM4EALDH1A1FBP1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1585775-A | 6-O-acyl ketolide derivatives of erythromycine useful as antibacterials | ORTHO MCNEIL PHARM INC (US) | 2005-02-23 | — | — | CN | disclosed |
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |