Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 9/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | KLK7 | P49862 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 8/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875969 | 1.00 | GAA (0.52) | GAAMCHR1MEN1KMT2AALDH1A1 | |
| SCHEMBL6456858 | 0.89 | KLK7 (0.62) | GAAMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL6456853 | 0.89 | KLK7 (0.62) | GAAMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL6877534 | 0.88 | MCHR1 (0.53) | MCHR1ADRA2ARAB9AMAPTRXFP1 | |
| SCHEMBL6877538 | 0.88 | MCHR1 (0.53) | MCHR1ADRA2ARAB9AMAPTRXFP1 | |
| SCHEMBL27651773 | 0.87 | MCHR1 (0.52) | GAAMCHR1KMT2AADRA2ARAB9A | |
| SCHEMBL6879865 | 0.86 | MCHR1 (0.57) | MCHR1LMNASMN1; SMN2ADRA2ARAB9A | |
| SCHEMBL6879862 | 0.86 | MCHR1 (0.57) | MCHR1LMNASMN1; SMN2ADRA2ARAB9A | |
| SCHEMBL6877059 | 0.85 | MCHR1 (0.51) | MCHR1ADRA2ARAB9AMAPTRXFP1 | |
| SCHEMBL6877064 | 0.85 | MCHR1 (0.51) | MCHR1ADRA2ARAB9AMAPTRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |