Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.53 |
| ▸ | MCHR1 | Q99705 | 9/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 8/20 | 0.51 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 3/20 | 0.44 |
| ▸ | HTR2B | P41595 | 3/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876238 | 1.00 | NPC1 (0.53) | NPC1RAB9AEPHX2MEN1LMNA | |
| SCHEMBL6875114 | 0.91 | MCHR1 (0.44) | NPC1RAB9AEPHX2MEN1LMNA | |
| SCHEMBL6875106 | 0.91 | MCHR1 (0.44) | NPC1RAB9AEPHX2MEN1LMNA | |
| SCHEMBL7109740 | 0.90 | NPC1 (0.54) | NPC1RAB9AEPHX2MCHR1ADRA2A | |
| SCHEMBL7109737 | 0.90 | NPC1 (0.54) | NPC1RAB9AEPHX2MCHR1ADRA2A | |
| SCHEMBL6880607 | 0.89 | PKM (0.55) | NPC1MEN1LMNAKMT2AMCHR1 | |
| SCHEMBL6868233 | 0.89 | KMT2A (0.53) | NPC1RAB9AEPHX2MEN1KMT2A | |
| SCHEMBL6879711 | 0.89 | MEN1 (0.53) | NPC1RAB9AEPHX2MEN1LMNA | |
| SCHEMBL6868229 | 0.89 | KMT2A (0.53) | NPC1RAB9AEPHX2MEN1KMT2A | |
| SCHEMBL6879704 | 0.89 | MEN1 (0.53) | NPC1RAB9AEPHX2MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |