Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 10/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.52 |
| ▸ | HRH1 | P35367 | 3/20 | 0.52 |
| ▸ | HTR2B | P41595 | 3/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | ALPG | P10696 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7109737 | 1.00 | NPC1 (0.54) | NPC1RAB9AMCHR1ADRA2AHRH1 | |
| SCHEMBL6876530 | 0.91 | MCHR1 (0.44) | NPC1RAB9AMCHR1ADRA2AHRH1 | |
| SCHEMBL6876522 | 0.91 | MCHR1 (0.44) | NPC1RAB9AMCHR1ADRA2AHRH1 | |
| SCHEMBL6880600 | 0.90 | PKM (0.55) | NPC1MCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6868233 | 0.90 | KMT2A (0.53) | NPC1RAB9AMCHR1ADRA2AHRH1 | |
| SCHEMBL6868229 | 0.90 | KMT2A (0.53) | NPC1RAB9AMCHR1ADRA2AHRH1 | |
| SCHEMBL6876244 | 0.90 | NPC1 (0.53) | NPC1RAB9AMCHR1ADRA2AHRH1 | |
| SCHEMBL6876238 | 0.90 | NPC1 (0.53) | NPC1RAB9AMCHR1ADRA2AHRH1 | |
| SCHEMBL6880607 | 0.90 | PKM (0.55) | NPC1MCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6871842 | 0.89 | SMN1; SMN2 (0.55) | NPC1RAB9AMCHR1ADRA2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |