Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 11/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 3/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | VCP | P55072 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6457227 | 1.00 | MCHR1 (0.43) | MCHR1ADRA2ANPY5RNOS1NOS2 | |
| SCHEMBL6868902 | 0.94 | MCHR1 (0.41) | MCHR1ADRA2ANPY5RNOS1NOS2 | |
| SCHEMBL6461592 | 0.94 | MCHR1 (0.41) | MCHR1ADRA2ANPY5RNOS1NOS2 | |
| SCHEMBL6876624 | 0.91 | MCHR1 (0.42) | MCHR1ADRA2ANPY5RADRA1AHTR2B | |
| SCHEMBL6876619 | 0.91 | MCHR1 (0.42) | MCHR1ADRA2ANPY5RADRA1AHTR2B | |
| SCHEMBL6462999 | 0.89 | MCHR1 (0.46) | MCHR1ADRA2ANPY5RDRD2MAPK14 | |
| SCHEMBL6875398 | 0.89 | MCHR1 (0.46) | MCHR1ADRA2ANPY5RDRD2MAPK14 | |
| SCHEMBL6459873 | 0.88 | APLNR (0.44) | MCHR1ADRA2ANPY5RCNR1CNR2 | |
| SCHEMBL6874596 | 0.88 | APLNR (0.44) | MCHR1ADRA2ANPY5RCNR1CNR2 | |
| SCHEMBL6456397 | 0.85 | MCHR1 (0.49) | MCHR1ADRA2ANPY5RADRA1AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |