Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CCNC | P24863 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 3/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876374 | 1.00 | NPC1 (0.57) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL6868346 | 0.91 | USP30 (0.46) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL6868351 | 0.91 | USP30 (0.46) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL6876710 | 0.91 | MCHR1 (0.50) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL6876707 | 0.91 | MCHR1 (0.50) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL6868693 | 0.90 | LMNA (0.45) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL6868701 | 0.90 | LMNA (0.45) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL6874872 | 0.89 | NPC1 (0.54) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL6874878 | 0.89 | NPC1 (0.54) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL6867915 | 0.89 | EPHX2 (0.49) | NPC1RAB9AMEN1KMT2AMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |