Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GALR2 | O43603 | 1/20 | 0.42 |
| ▸ | GALR1 | P47211 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6868701 | 1.00 | LMNA (0.45) | LMNAALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6872800 | 0.91 | MCHR1 (0.46) | SMN1; SMN2NPC1RAB9AMCHR1ADRA2A | |
| SCHEMBL6872807 | 0.91 | MCHR1 (0.46) | SMN1; SMN2NPC1RAB9AMCHR1ADRA2A | |
| SCHEMBL6876374 | 0.90 | NPC1 (0.57) | LMNAALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6876368 | 0.90 | NPC1 (0.57) | LMNAALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6868231 | 0.89 | BCHE (0.46) | LMNAALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6868226 | 0.89 | BCHE (0.46) | LMNAALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6871842 | 0.88 | SMN1; SMN2 (0.55) | LMNAALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6871841 | 0.88 | SMN1; SMN2 (0.55) | LMNAALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6869110 | 0.88 | ADRA2A (0.38) | LMNASMN1; SMN2RAB9AMCHR1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |