Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 9/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.49 |
| ▸ | HTR2B | P41595 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876753 | 1.00 | MCHR1 (0.53) | MCHR1AURKAAURKBADRA2AADRA1A | |
| SCHEMBL6879858 | 0.89 | LMNA (0.57) | MCHR1AURKAAURKBADRA2AADRA1A | |
| SCHEMBL6879853 | 0.89 | LMNA (0.57) | MCHR1AURKAAURKBADRA2AADRA1A | |
| SCHEMBL6874037 | 0.89 | AURKA (0.50) | MCHR1AURKAAURKBADRA2AADRA1A | |
| SCHEMBL6874044 | 0.89 | AURKA (0.50) | MCHR1AURKAAURKBADRA2AADRA1A | |
| SCHEMBL6868664 | 0.89 | MCHR1 (0.50) | MCHR1AURKAAURKBADRA2AADRA1A | |
| SCHEMBL6868658 | 0.89 | MCHR1 (0.50) | MCHR1AURKAAURKBADRA2AADRA1A | |
| SCHEMBL6458834 | 0.89 | MCHR1 (0.57) | MCHR1AURKAAURKBADRA2AADRA1A | |
| SCHEMBL6458825 | 0.89 | MCHR1 (0.57) | MCHR1AURKAAURKBADRA2AADRA1A | |
| Hydrochloric Acid SCHEMBL6459091 | 0.88 | MCHR1 (0.56) | MCHR1AURKAAURKBADRA2AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |