Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MCHR1 | Q99705 | 9/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.53 |
| ▸ | HRH1 | P35367 | 3/20 | 0.53 |
| ▸ | HTR2B | P41595 | 3/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.44 |
| ▸ | ATF4 | P18848 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 3/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6879858 | 1.00 | LMNA (0.57) | LMNAMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6876747 | 0.89 | MCHR1 (0.53) | LMNAMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6876753 | 0.89 | MCHR1 (0.53) | LMNAMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6874044 | 0.89 | AURKA (0.50) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6874037 | 0.89 | AURKA (0.50) | MCHR1ADRA2AHRH1HTR2BADRA1A | |
| SCHEMBL6456315 | 0.89 | MCHR1 (0.50) | LMNAMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6456307 | 0.89 | MCHR1 (0.50) | LMNAMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6875733 | 0.89 | MCHR1 (0.53) | LMNAMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6875739 | 0.89 | MCHR1 (0.53) | LMNAMCHR1ADRA2AHRH1HTR2B | |
| SCHEMBL6869412 | 0.88 | EPHX2 (0.55) | MCHR1POLBAURKAAURKBSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |