Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 15/20 | 0.64 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.37 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6883012 | 0.83 | ADORA2A (0.44) | ADORA2A | |
| SCHEMBL6886922 | 0.83 | DHODH (0.47) | ADORA2A | |
| SCHEMBL6882930 | 0.82 | ADORA2A (0.67) | ADORA2AADORA3KDM4E | |
| SCHEMBL6876885 | 0.81 | ADORA2A (0.63) | ADORA2AADORA3 | |
| SCHEMBL6877248 | 0.81 | ADORA2A (0.63) | ADORA2AADORA3HDAC1HDAC3HDAC2 | |
| SCHEMBL6885332 | 0.80 | ADORA2A (0.67) | ADORA2A | |
| SCHEMBL6885020 | 0.80 | ADORA2A (0.61) | ADORA2AADORA3HDAC1HDAC3HDAC2 | |
| SCHEMBL989657 | 0.79 | ADORA2A (0.60) | ADORA2AHDAC1HDAC3HDAC2KDM4E | |
| SCHEMBL6884914 | 0.78 | ADORA2A (0.64) | ADORA2A | |
| SCHEMBL6887128 | 0.78 | ADORA2A (1.00) | ADORA2AHDAC1HDAC3HDAC2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689790-B2 | 8-AMINO-6-AMIDO-SUBSTITUTED-(1,2,4)TRIAZOLO(1,5-A)PYRIDINES; ADENOSINE RECEPTOR MODULATERS | HOFFMANN-LA ROCHE INC. | 2004-02-10 | — | — | US | disclosed |