Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 17/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876889 | 0.83 | ADORA2A (0.64) | ADORA2A | |
| SCHEMBL6883434 | 0.82 | ADORA2A (0.46) | ADORA2AMEN1KMT2A | |
| SCHEMBL6886922 | 0.81 | DHODH (0.47) | ADORA2A | |
| SCHEMBL6879225 | 0.81 | ADORA2A (0.62) | ADORA2ANPC1 | |
| SCHEMBL6876856 | 0.81 | ADORA2A (0.64) | ADORA2A | |
| SCHEMBL6883010 | 0.81 | ADORA2A (0.64) | ADORA2A | |
| SCHEMBL6879136 | 0.79 | ADORA2A (0.70) | ADORA2ANPC1KMT2A | |
| SCHEMBL6884874 | 0.79 | ADORA2A (0.67) | ADORA2A | |
| SCHEMBL6883910 | 0.78 | ADORA2A (0.69) | ADORA2AKMT2A | |
| SCHEMBL6882517 | 0.78 | ADORA2A (0.63) | ADORA2AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689790-B2 | 8-AMINO-6-AMIDO-SUBSTITUTED-(1,2,4)TRIAZOLO(1,5-A)PYRIDINES; ADENOSINE RECEPTOR MODULATERS | HOFFMANN-LA ROCHE INC. | 2004-02-10 | — | — | US | disclosed |