Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 6/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877351 | 1.00 | MCHR1 (0.45) | MCHR1ADRA2ANPY5RCD274MAPT | |
| SCHEMBL6455511 | 0.93 | MCHR1 (0.46) | MCHR1ADRA2ANPY5RCD274MAPT | |
| SCHEMBL6868214 | 0.93 | MCHR1 (0.46) | MCHR1ADRA2ANPY5RCD274MAPT | |
| SCHEMBL6873489 | 0.89 | MCHR1 (0.48) | MCHR1ADRA2ANPY5RTP53APP | |
| SCHEMBL6873484 | 0.89 | MCHR1 (0.48) | MCHR1ADRA2ANPY5RTP53APP | |
| SCHEMBL6877323 | 0.89 | MCHR1 (0.44) | MCHR1ADRA2ANPY5RMAPTAPP | |
| SCHEMBL6877318 | 0.89 | MCHR1 (0.44) | MCHR1ADRA2ANPY5RMAPTAPP | |
| SCHEMBL6873885 | 0.88 | MCHR1 (0.46) | MCHR1ADRA2ANPY5RMAPTTP53 | |
| SCHEMBL6873877 | 0.88 | MCHR1 (0.46) | MCHR1ADRA2ANPY5RMAPTTP53 | |
| SCHEMBL6877690 | 0.87 | MCHR1 (0.48) | MCHR1ADRA2ANPY5RMAPTAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |