Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6457586 | 1.00 | MAPK8 (0.42) | MAPK8MAPK9MAPK10DRD2DRD3 | |
| SCHEMBL6868661 | 0.90 | CNR1 (0.41) | MAPK8MAPK9MAPK10DRD2DRD3 | |
| SCHEMBL6868672 | 0.90 | CNR1 (0.41) | MAPK8MAPK9MAPK10DRD2DRD3 | |
| SCHEMBL6464818 | 0.89 | SMN1; SMN2 (0.46) | MAPK8MAPK9MAPK10DRD2DRD3 | |
| SCHEMBL6878199 | 0.89 | SMN1; SMN2 (0.46) | MAPK8MAPK9MAPK10DRD2DRD3 | |
| SCHEMBL6875327 | 0.89 | CCNT1 (0.43) | MAPK8MAPK9MAPK10DRD2DRD3 | |
| SCHEMBL6875315 | 0.89 | CCNT1 (0.43) | MAPK8MAPK9MAPK10DRD2DRD3 | |
| SCHEMBL6879311 | 0.88 | MAPK8 (0.43) | MAPK8MAPK9MAPK10DRD2DRD3 | |
| SCHEMBL6879316 | 0.88 | MAPK8 (0.43) | MAPK8MAPK9MAPK10DRD2DRD3 | |
| SCHEMBL6873584 | 0.85 | MCHR1 (0.42) | MAPK8MAPK9MAPK10DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |