Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 15/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 8/20 | 0.56 |
| ▸ | HTR2B | P41595 | 6/20 | 0.56 |
| ▸ | HRH1 | P35367 | 5/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | SELP | P16109 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6873929 | 0.89 | MCHR1 (0.55) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6873926 | 0.89 | MCHR1 (0.55) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6875152 | 0.86 | MCHR1 (0.53) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6875146 | 0.86 | MCHR1 (0.53) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6877606 | 0.85 | TSHR (0.50) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6464429 | 0.85 | TSHR (0.50) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6879245 | 0.84 | MCHR1 (0.63) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6879241 | 0.84 | MCHR1 (0.63) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6875990 | 0.84 | MCHR1 (0.63) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6875998 | 0.84 | MCHR1 (0.63) | MCHR1ADRA2AHTR2BHRH1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |