Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 11/20 | 0.63 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.63 |
| ▸ | HTR2B | P41595 | 6/20 | 0.63 |
| ▸ | HRH1 | P35367 | 5/20 | 0.63 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | HTR5A | P47898 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6879241 | 1.00 | MCHR1 (0.63) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6875152 | 0.86 | MCHR1 (0.53) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6875998 | 0.86 | MCHR1 (0.63) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6875990 | 0.86 | MCHR1 (0.63) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6875146 | 0.86 | MCHR1 (0.53) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6877675 | 0.84 | MCHR1 (0.62) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6875844 | 0.84 | MCHR1 (0.48) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6875836 | 0.84 | MCHR1 (0.48) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6874493 | 0.83 | MCHR1 (0.53) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6873926 | 0.83 | MCHR1 (0.55) | MCHR1ADRA2AHTR2BHRH1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |