Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 8/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877812 | 1.00 | MCHR1 (0.43) | MCHR1CNR2BACE1ADRA2AADRA1A | |
| SCHEMBL6880113 | 0.90 | MTNR1A (0.42) | MCHR1CNR2ADRA2AADRA1AHTR2B | |
| SCHEMBL6880107 | 0.90 | MTNR1A (0.42) | MCHR1CNR2ADRA2AADRA1AHTR2B | |
| SCHEMBL6457031 | 0.83 | MCHR1 (0.43) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6457021 | 0.83 | MCHR1 (0.43) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6873830 | 0.83 | MCHR1 (0.45) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6873825 | 0.83 | MCHR1 (0.45) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6456731 | 0.83 | MCHR1 (0.42) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6456719 | 0.83 | MCHR1 (0.42) | MCHR1ADRA2AADRA1AHTR2BHRH1 | |
| SCHEMBL6866999 | 0.82 | CNR2 (0.48) | MCHR1CNR2ADRA2AADRA1AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |