Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 8/20 | 0.40 |
| ▸ | CNR2 | P34972 | 7/20 | 0.40 |
| ▸ | CNR1 | P21554 | 5/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6880107 | 1.00 | MTNR1A (0.42) | MTNR1AMTNR1BHPGDHTTRECQL | |
| SCHEMBL6877817 | 0.90 | MCHR1 (0.43) | HPGDMCHR1CNR2CNR1MAPK8 | |
| SCHEMBL6877812 | 0.90 | MCHR1 (0.43) | HPGDMCHR1CNR2CNR1MAPK8 | |
| SCHEMBL6877124 | 0.87 | EPHX2 (0.47) | MCHR1CYP2C9CCNE1CDK2MAPK8 | |
| SCHEMBL6877131 | 0.87 | EPHX2 (0.47) | MCHR1CYP2C9CCNE1CDK2MAPK8 | |
| SCHEMBL6868909 | 0.82 | SIGMAR1 (0.46) | MCHR1CYP2C9CCNE1CDK2MAPK8 | |
| SCHEMBL6868904 | 0.82 | SIGMAR1 (0.46) | MCHR1CYP2C9CCNE1CDK2MAPK8 | |
| SCHEMBL6874860 | 0.82 | ALDH1A1 (0.41) | MCHR1CYP2C9CCNE1CDK2MAPK8 | |
| SCHEMBL6874855 | 0.82 | ALDH1A1 (0.41) | MCHR1CYP2C9CCNE1CDK2MAPK8 | |
| SCHEMBL6874044 | 0.81 | AURKA (0.50) | MCHR1CYP2C9CCNE1CDK2MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |