Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PTPRA | P18433 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6878942 | 0.84 | IDO1 (0.36) | IDO1RAB9ANPC1CYP1A2ALDH1A1 | |
| SCHEMBL6879541 | 0.74 | IDO1 (0.54) | IDO1CYP1A2 | |
| SCHEMBL9911543 | 0.71 | CYP1A2 (0.54) | RAB9ANPC1CYP1A2ALDH1A1MAPT | |
| SCHEMBL10811019 | 0.70 | NSD2 (0.50) | IDO1RAB9ANPC1CYP1A2ALDH1A1 | |
| SCHEMBL28408612 | 0.70 | RAB9A (0.71) | IDO1RAB9ANPC1CYP1A2ALDH1A1 | |
| SCHEMBL10412713 | 0.69 | RAB9A (0.60) | IDO1RAB9ANPC1CYP1A2ALDH1A1 | |
| SCHEMBL14760273 | 0.69 | RAB9A (0.51) | IDO1RAB9ANPC1CYP1A2ALDH1A1 | |
| SCHEMBL30454690 | 0.69 | RAB9A (0.60) | IDO1RAB9ANPC1CYP1A2ALDH1A1 | |
| SCHEMBL6011931 | 0.69 | RAB9A (0.75) | IDO1RAB9ANPC1CYP1A2ALDH1A1 | |
| SCHEMBL2051943 | 0.69 | RAB9A (0.75) | IDO1RAB9ANPC1CYP1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130040998-A1 | FLUORINATED HDAC INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2013-02-14 | — | — | US | disclosed |
| WO-2011084991-A2 | FLUORINATED HDAC INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-07-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130040998-A1 | FLUORINATED HDAC INHIBITORS AND USES THEREOF | HDAC1, HDAC5, HDAC6 | IDO1 1667/4885RAB9A 913/4885NPC1 412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.