Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | CCNK | O75909 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877903 | 1.00 | MCHR1 (0.42) | MCHR1ADRA2ANPY5REPHX1AR | |
| SCHEMBL6874935 | 0.90 | NPY5R (0.43) | MCHR1ADRA2ANPY5REPHX1NPC1 | |
| SCHEMBL6874942 | 0.90 | NPY5R (0.43) | MCHR1ADRA2ANPY5REPHX1NPC1 | |
| SCHEMBL6878082 | 0.89 | ALDH1A1 (0.46) | MCHR1ADRA2ANPY5REPHX1NPC1 | |
| SCHEMBL6878078 | 0.89 | ALDH1A1 (0.46) | MCHR1ADRA2ANPY5REPHX1NPC1 | |
| SCHEMBL6878657 | 0.89 | EPHX1 (0.49) | MCHR1ADRA2AEPHX1 | |
| SCHEMBL6878665 | 0.89 | EPHX1 (0.49) | MCHR1ADRA2AEPHX1 | |
| SCHEMBL7043797 | 0.88 | AR (0.53) | MCHR1ADRA2ANPY5RAR | |
| SCHEMBL7043795 | 0.88 | AR (0.53) | MCHR1ADRA2ANPY5RAR | |
| SCHEMBL6878072 | 0.87 | NPC1 (0.44) | MCHR1ADRA2ANPY5REPHX1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |