Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6878665 | 1.00 | EPHX1 (0.49) | EPHX1MCHR1ADRA2AEPHX2LMNA | |
| SCHEMBL6868161 | 0.89 | MCHR1 (0.45) | MCHR1ADRA2ALMNASMN1; SMN2KDM4E | |
| SCHEMBL6868153 | 0.89 | MCHR1 (0.45) | MCHR1ADRA2ALMNASMN1; SMN2KDM4E | |
| SCHEMBL6877892 | 0.89 | MCHR1 (0.42) | EPHX1MCHR1ADRA2A | |
| SCHEMBL6877903 | 0.89 | MCHR1 (0.42) | EPHX1MCHR1ADRA2A | |
| SCHEMBL6877703 | 0.87 | MCHR1 (0.59) | MCHR1ADRA2ALMNASMN1; SMN2KDM4E | |
| SCHEMBL6877713 | 0.87 | MCHR1 (0.59) | MCHR1ADRA2ALMNASMN1; SMN2KDM4E | |
| SCHEMBL6877589 | 0.86 | EPHX1 (0.53) | EPHX1MCHR1ADRA2AEPHX2 | |
| SCHEMBL6880103 | 0.86 | SIGMAR1 (0.48) | EPHX1MCHR1ADRA2ALMNASMN1; SMN2 | |
| SCHEMBL6880110 | 0.86 | SIGMAR1 (0.48) | EPHX1MCHR1ADRA2ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |