Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.45 |
| ▸ | HRH1 | P35367 | 3/20 | 0.45 |
| ▸ | HTR2B | P41595 | 3/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877944 | 1.00 | NPC1 (0.55) | NPC1MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL6876054 | 0.91 | MCHR1 (0.46) | NPC1MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL6876048 | 0.91 | MCHR1 (0.46) | NPC1MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL6876068 | 0.90 | ALDH1A1 (0.48) | NPC1MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL6880026 | 0.88 | MCHR1 (0.44) | NPC1MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL6880018 | 0.88 | MCHR1 (0.44) | NPC1MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL6878555 | 0.88 | MCHR1 (0.42) | NPC1MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL6878558 | 0.88 | MCHR1 (0.42) | NPC1MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL6457829 | 0.85 | MCHR1 (0.43) | NPC1MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL6457834 | 0.85 | MCHR1 (0.43) | NPC1MEN1KMT2AMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |