Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 10/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 10/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 10/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 10/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 10/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.44 |
| ▸ | GABRA6 | Q16445 | 7/20 | 0.44 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | GABRE | P78334 | 1/20 | 0.38 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.38 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.38 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11965472 | 0.86 | GAA (0.47) | IDO1FLT3HPGDKDM4EMEN1 | |
| SCHEMBL28046328 | 0.77 | HRH4 (0.52) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL6877620 | 0.75 | KMT2A (0.41) | FLT3HPGDKDM4EMEN1KMT2A | |
| SCHEMBL25474879 | 0.72 | EIF4A3 (0.44) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL3969314 | 0.72 | GABRA1 (0.44) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL29035004 | 0.72 | FLT3 (0.59) | IDO1FLT3KDM4EMEN1KMT2A | |
| SCHEMBL22647484 | 0.72 | CYP1A2 (0.46) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL31513837 | 0.71 | HRH4 (0.52) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL3964313 | 0.71 | HRH4 (0.52) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL5564109 | 0.71 | KMT2A (0.57) | FLT3HPGDKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1474420-A1 | QUINAZOLINE COMPOUNDS | Astrazeneca AB (SE) | 2004-11-10 | — | — | EP | disclosed |
| WO-2003064413-A1 | QUINAZOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-07 | — | — | WO | disclosed |
| EP-1313726-A1 | QUINOLINE DERIVATIVES HAVING VEGF INHIBITING ACTIVITY | AstraZeneca AB (SE) | 2003-05-28 | — | — | EP | disclosed |
| EP-1311500-A2 | INDOLE, AZAINDOLE AND INDAZOLE DERIVATIVES HAVING VEGF INHIBITING ACTIVITY | AstraZeneca AB (SE) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002012227-A2 | INDOLE, AZAINDOLE AND INDAZOLE DERIVATIVES HAVING VEGF INHIBITING ACTIVITY | ASTRAZENECA AB (SE) | 2002-02-14 | — | — | WO | disclosed |
| WO-2002012226-A1 | QUINOLINE DERIVATIVES HAVING VEGF INHIBITING ACTIVITY | ASTRAZENECA AB (SE) | 2002-02-14 | — | — | WO | disclosed |
| EP-1154774-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AstraZeneca AB (SE) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000047212-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2000-08-17 | — | — | WO | disclosed |