Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4A3 | P38919 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.42 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.42 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | GABRE | P78334 | 1/20 | 0.36 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.36 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.36 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27893658 | 0.86 | GABRA1 (0.41) | EIF4A3GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL29897794 | 0.83 | ULK1 (0.49) | EIF4A3CNR1MEN1KMT2AIDO1 | |
| SCHEMBL4276853 | 0.83 | ULK1 (0.49) | EIF4A3CNR1MEN1KMT2AIDO1 | |
| SCHEMBL25474875 | 0.82 | EIF4A3 (0.40) | EIF4A3GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL28046328 | 0.81 | HRH4 (0.52) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL2820122 | 0.79 | KDM4E (0.50) | EIF4A3CNR1MEN1KMT2AKDM4E | |
| SCHEMBL16234661 | 0.78 | EIF4A3 (0.51) | EIF4A3CNR1IDO1TDO2KDM4E | |
| SCHEMBL29655546 | 0.77 | EIF4A3 (0.63) | EIF4A3CNR1MEN1KMT2AIDO1 | |
| SCHEMBL1144892 | 0.77 | EIF4A3 (0.63) | EIF4A3CNR1MEN1KMT2AIDO1 | |
| SCHEMBL28909245 | 0.76 | EIF4A3 (0.46) | EIF4A3GABRA1GABRG2GABRB3GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11912714-B2 | Spiropyrrolidine derived antiviral agents | ENANTA PHARMACEUTICALS, INC. (US) | 2024-02-27 | — | — | US | disclosed |
| WO-2023086352-A1 | NOVEL SPIROPYRROLIDINE DERIVED ANTIVIRAL AGENTS | ENANTA PHARMACEUTICALS, INC. (US) | 2023-05-19 | — | — | WO | disclosed |
| US-20230151019-A1 | NOVEL SPIROPYRROLIDINE DERIVED ANTIVIRAL AGENTS | ENANTA PHARMACEUTICALS, INC. | 2023-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230151019-A1 | NOVEL SPIROPYRROLIDINE DERIVED ANTIVIRAL AGENTS | ACE, ACE2, PKD1 | EIF4A3 218/4885GABRA1 3912/4885GABRG2 4589/4885 |
| US-11912714-B2 | Spiropyrrolidine derived antiviral agents | ACE, ACE2, PKD1 | EIF4A3 582/4885GABRA1 3746/4885GABRG2 4633/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.