Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 12/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 9/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6878013 | 1.00 | MCHR1 (0.47) | MCHR1SIGMAR1ADRA2ATP53KDM4E | |
| SCHEMBL6868396 | 0.90 | MCHR1 (0.44) | MCHR1SIGMAR1ADRA2AKDM4ELMNA | |
| SCHEMBL6868405 | 0.90 | MCHR1 (0.44) | MCHR1SIGMAR1ADRA2AKDM4ELMNA | |
| SCHEMBL27653033 | 0.89 | SIGMAR1 (0.50) | MCHR1SIGMAR1ADRA2ATP53KDM4E | |
| SCHEMBL6462142 | 0.89 | MCHR1 (0.47) | MCHR1SIGMAR1ADRA2ATP53KDM4E | |
| SCHEMBL6462141 | 0.89 | MCHR1 (0.47) | MCHR1SIGMAR1ADRA2ATP53KDM4E | |
| SCHEMBL6872998 | 0.87 | MCHR1 (0.51) | MCHR1SIGMAR1ADRA2AKDM4ELMNA | |
| SCHEMBL6872993 | 0.87 | MCHR1 (0.51) | MCHR1SIGMAR1ADRA2AKDM4ELMNA | |
| SCHEMBL6459479 | 0.84 | SIGMAR1 (0.52) | MCHR1SIGMAR1SMN1; SMN2NPY5RMAPT | |
| SCHEMBL6459469 | 0.84 | SIGMAR1 (0.52) | MCHR1SIGMAR1SMN1; SMN2NPY5RMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |