Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 6/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 6/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.41 |
| ▸ | ITGAV | P06756 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | VCP | P55072 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | ACACA | Q13085 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6868396 | 1.00 | MCHR1 (0.44) | MCHR1NPY5RADRA2AITGB3ITGAV | |
| SCHEMBL6867585 | 0.90 | MCHR1 (0.45) | MCHR1NPY5RADRA2AITGB3ITGAV | |
| SCHEMBL6867592 | 0.90 | MCHR1 (0.45) | MCHR1NPY5RADRA2AITGB3ITGAV | |
| SCHEMBL6878013 | 0.90 | MCHR1 (0.47) | MCHR1NPY5RADRA2AKDM4ELMNA | |
| SCHEMBL6878006 | 0.90 | MCHR1 (0.47) | MCHR1NPY5RADRA2AKDM4ELMNA | |
| SCHEMBL6461455 | 0.90 | MCHR1 (0.44) | MCHR1NPY5RADRA2AITGB3ITGAV | |
| SCHEMBL6461446 | 0.90 | MCHR1 (0.44) | MCHR1NPY5RADRA2AITGB3ITGAV | |
| SCHEMBL6879386 | 0.88 | MCHR1 (0.47) | MCHR1NPY5RADRA2AITGB3ITGAV | |
| SCHEMBL6879382 | 0.88 | MCHR1 (0.47) | MCHR1NPY5RADRA2AITGB3ITGAV | |
| SCHEMBL6878858 | 0.86 | MCHR1 (0.51) | MCHR1NPY5RADRA2AACACBACACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |