Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 8/20 | 0.53 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.43 |
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6878027 | 1.00 | MCHR1 (0.53) | MCHR1USP2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6877157 | 0.91 | MCHR1 (0.51) | MCHR1USP2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6877152 | 0.91 | MCHR1 (0.51) | MCHR1USP2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6455511 | 0.89 | MCHR1 (0.46) | MCHR1USP2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6868214 | 0.89 | MCHR1 (0.46) | MCHR1USP2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6873630 | 0.86 | MCHR1 (0.51) | MCHR1USP2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6879016 | 0.86 | MCHR1 (0.51) | MCHR1USP2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6873635 | 0.86 | MCHR1 (0.51) | MCHR1USP2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6867441 | 0.86 | MCHR1 (0.58) | MCHR1APPBCHEACHELMNA | |
| SCHEMBL6879011 | 0.86 | MCHR1 (0.51) | MCHR1USP2CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |