Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL688464 | 0.90 | MEN1 (0.40) | KMT2AALDH1A1MEN1KDM4EHTT | |
| SCHEMBL688254 | 0.90 | SMN1; SMN2 (0.44) | SMN1; SMN2KMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL687874 | 0.88 | MAPT (0.44) | KMT2AALDH1A1MEN1KDM4EHTT | |
| SCHEMBL687096 | 0.87 | MEN1 (0.43) | SMN1; SMN2KMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL686624 | 0.86 | MEN1 (0.42) | KMT2AALDH1A1MEN1KDM4EHTT | |
| SCHEMBL686857 | 0.85 | SMN1; SMN2 (0.41) | SMN1; SMN2KMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL687242 | 0.84 | SMN1; SMN2 (0.44) | SMN1; SMN2KMT2AMEN1NPSR1POLB | |
| SCHEMBL687038 | 0.84 | SMN1; SMN2 (0.43) | SMN1; SMN2KMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL687629 | 0.83 | SMN1; SMN2 (0.45) | SMN1; SMN2KMT2AMEN1NPSR1POLB | |
| SCHEMBL686627 | 0.83 | SMN1; SMN2 (0.42) | SMN1; SMN2KMT2AMEN1NPSR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |