Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER3 | P43115 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGAV | P06756 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 12/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 12/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687832 | 0.85 | PTGER3 (0.41) | PTGER3KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL687918 | 0.85 | KDM4E (0.44) | PTGER3KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL688384 | 0.85 | KDM4E (0.42) | PTGER3KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL687577 | 0.83 | PTGER3 (0.44) | PTGER3KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL686924 | 0.83 | PTGER3 (0.39) | PTGER3KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL687241 | 0.83 | PTGER3 (0.50) | PTGER3KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL687937 | 0.83 | PTGER3 (0.45) | PTGER3KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL686747 | 0.83 | MEN1 (0.39) | PTGER3KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL687728 | 0.82 | ITGB3 (0.41) | MEN1KMT2AITGB3ITGAV | |
| SCHEMBL687894 | 0.82 | HDAC3 (0.37) | PTGER3KDM4EMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1176956-B1 | CARBOXYLIC ACID DERIVATIVES THAT INHIBIT THE BINDING OF INTEGRINS TO THEIR RECEPTORS | ENCYSIVE PHARMACEUTICALS INC (US) | 2008-01-09 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |