Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 14/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 12/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6879263 | 1.00 | MCHR1 (0.47) | MCHR1ADRA2ARAB9ANPC1HTR1A | |
| SCHEMBL27652990 | 0.86 | MCHR1 (0.50) | MCHR1ADRA2ARAB9AHTR1AADRA1A | |
| SCHEMBL6463528 | 0.86 | RAB9A (0.49) | MCHR1ADRA2ARAB9AHTR1AADRA1A | |
| SCHEMBL6461330 | 0.86 | RAB9A (0.49) | MCHR1ADRA2ARAB9AHTR1AADRA1A | |
| SCHEMBL6467599 | 0.84 | MCHR1 (0.48) | MCHR1ADRA2ARAB9ANPC1HTR1A | |
| SCHEMBL6460413 | 0.84 | MCHR1 (0.48) | MCHR1ADRA2ARAB9ANPC1HTR1A | |
| SCHEMBL6879865 | 0.83 | MCHR1 (0.57) | MCHR1ADRA2ARAB9AHTR1AADRA1A | |
| SCHEMBL6879862 | 0.83 | MCHR1 (0.57) | MCHR1ADRA2ARAB9AHTR1AADRA1A | |
| SCHEMBL6464493 | 0.83 | MCHR1 (0.59) | MCHR1ADRA2ARAB9AHTR1AADRA1A | |
| SCHEMBL6455845 | 0.83 | MCHR1 (0.57) | MCHR1ADRA2ARAB9AHTR1AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |