Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6879363 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2KDM4ELMNAMCHR1ADRA2A | |
| SCHEMBL6877176 | 0.91 | TP53 (0.47) | SMN1; SMN2KDM4ELMNAMCHR1ADRA2A | |
| SCHEMBL6877168 | 0.91 | TP53 (0.47) | SMN1; SMN2KDM4ELMNAMCHR1ADRA2A | |
| SCHEMBL6877615 | 0.90 | GAA (0.51) | SMN1; SMN2KDM4ELMNAMCHR1ADRA2A | |
| SCHEMBL6877624 | 0.90 | GAA (0.51) | SMN1; SMN2KDM4ELMNAMCHR1ADRA2A | |
| SCHEMBL6877266 | 0.89 | SMN1; SMN2 (0.44) | SMN1; SMN2KDM4ELMNAMCHR1ADRA2A | |
| SCHEMBL6458568 | 0.89 | SMN1; SMN2 (0.43) | SMN1; SMN2KDM4ELMNAMCHR1ADRA2A | |
| SCHEMBL6873091 | 0.89 | KDM4E (0.43) | SMN1; SMN2KDM4ELMNAMCHR1ADRA2A | |
| SCHEMBL6877259 | 0.89 | SMN1; SMN2 (0.44) | SMN1; SMN2KDM4ELMNAMCHR1ADRA2A | |
| SCHEMBL6873096 | 0.89 | KDM4E (0.43) | SMN1; SMN2KDM4ELMNAMCHR1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |