Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 9/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727715 | 0.86 | TNFRSF1A (0.44) | TNFRSF1AMAPTRXFP1ERN1KDM4E | |
| SCHEMBL5560851 | 0.84 | L3MBTL1 (0.39) | TNFRSF1ACA2CA9MAPTRXFP1 | |
| SCHEMBL5566988 | 0.83 | KMT2A (0.51) | RXFP1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL5560061 | 0.83 | TNFRSF1A (0.41) | TNFRSF1ACA2CA9MAPTRXFP1 | |
| SCHEMBL5565370 | 0.82 | MEN1 (0.51) | RXFP1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL5566178 | 0.82 | TNFRSF1A (0.39) | TNFRSF1ACA2CA9MAPTRXFP1 | |
| SCHEMBL5561089 | 0.82 | TNFRSF1A (0.39) | TNFRSF1ACA2CA9MAPTRXFP1 | |
| SCHEMBL5564501 | 0.82 | RXFP1 (0.39) | TNFRSF1ACA2CA9MAPTRXFP1 | |
| SCHEMBL5560946 | 0.82 | RXFP1 (0.49) | RXFP1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL5565448 | 0.81 | CA2 (0.36) | TNFRSF1ACA2CA9MAPTRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004108094-A2 | SULFONAMIDE-SUBSTITUTED CHALCONE DERIVATIVES AND THEIR USE TO TREAT DISEASES | ATHEROGENICS, INC. (US) | 2004-12-16 | — | — | WO | claimed |
| WO-2004108094-A2 | SULFONAMIDE-SUBSTITUTED CHALCONE DERIVATIVES AND THEIR USE TO TREAT DISEASES | ATHEROGENICS, INC. (US) | 2004-12-16 | — | — | WO | disclosed |