Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 6/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | PI4KA | P42356 | 1/20 | 0.45 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5423047 | 0.84 | NOTUM (0.39) | NOTUMPIK3CAPI4KAPI4KBEGLN1 | |
| SCHEMBL510846 | 0.83 | — | — | |
| SCHEMBL5114909 | 0.82 | PIK3CA (0.46) | NOTUMPIK3CAPI4KAPI4KBNPC1 | |
| SCHEMBL4592575 | 0.82 | GFER (0.46) | NOTUMEGLN1LTA4HMAP4K4CYP1A2 | |
| SCHEMBL22184935 | 0.80 | PTGS1 (0.47) | NOTUMEGLN1LTA4HCYP1A2KCNH2 | |
| SCHEMBL22920103 | 0.80 | PIK3CA (0.45) | PIK3CAPI4KAPI4KBEGLN1MAP4K4 | |
| SCHEMBL19835433 | 0.77 | NOTUM (0.49) | NOTUMMAP4K4CYP1A2KCNH2MINK1 | |
| SCHEMBL21770489 | 0.76 | PIK3CA (0.42) | PIK3CAPI4KAPI4KBNPC1RAB9A | |
| SCHEMBL4415453 | 0.76 | KIF11 (0.47) | NOTUMPIK3CAPI4KAPI4KBMAP4K4 | |
| SCHEMBL7497693 | 0.74 | CYP2A6 (0.46) | PIK3CAPI4KAPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1286822-C | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-11-29 | — | — | CN | disclosed |
| EP-1479671-A1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2004-11-24 | — | — | EP | disclosed |
| CN-1358175-A | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2002-07-10 | — | — | CN | disclosed |
| EP-1175408-A1 | PYRIMIDINONE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000066567-A1 | PYRIMIDINONE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-09 | — | — | WO | disclosed |