Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.74 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.74 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.74 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.74 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.74 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.74 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.74 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.74 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.74 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.74 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.74 |
| ▸ | POLB | P06746 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.58 |
| ▸ | FAAH | O00519 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15480449 | 0.91 | HDAC3 (0.88) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL28253513 | 0.86 | HDAC3 (0.76) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL27813733 | 0.85 | LMNA (0.97) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Pyroxamide SCHEMBL154681 | 0.85 | HDAC1 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL8277953 | 0.85 | HDAC3 (0.78) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Pyroxamide SCHEMBL30184775 | 0.85 | HDAC1 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL13477810 | 0.85 | LMNA (0.81) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL5956924 | 0.85 | HDAC1 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL30444393 | 0.84 | LMNA (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL823570 | 0.84 | LMNA (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011084991-A2 | FLUORINATED HDAC INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-07-14 | — | — | WO | disclosed |