Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6879678 | 1.00 | TSHR (0.54) | TSHRLMNACYP3A4CYP2C19MCHR1 | |
| SCHEMBL6456529 | 0.87 | TACR3 (0.47) | TSHRMCHR1GAAADRA2A | |
| SCHEMBL6456527 | 0.87 | TACR3 (0.47) | TSHRMCHR1GAAADRA2A | |
| SCHEMBL4215618 | 0.84 | MCHR1 (0.56) | TSHRLMNAMCHR1ADRA2A | |
| SCHEMBL4028824 | 0.84 | MCHR1 (0.56) | TSHRLMNAMCHR1ADRA2A | |
| SCHEMBL4028822 | 0.84 | MCHR1 (0.56) | TSHRLMNAMCHR1ADRA2A | |
| SCHEMBL27632422 | 0.81 | ALDH1A1 (0.43) | LMNAMCHR1ADRA2A | |
| SCHEMBL27651737 | 0.81 | MCHR1 (0.45) | LMNAMCHR1ADRA2AKMT2A | |
| SCHEMBL6867524 | 0.81 | ELANE (0.44) | TSHRLMNAMCHR1ADRA2A | |
| SCHEMBL6876320 | 0.81 | MCHR1 (0.41) | MCHR1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |