Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | EIF4E | P06730 | 5/20 | 0.42 |
| ▸ | GNRHR | P30968 | 3/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5043491 | 0.90 | EIF4E (0.43) | NOTUMEIF4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6879341 | 0.88 | EIF4E (0.45) | NOTUMEIF4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6872874 | 0.87 | NOTUM (0.42) | NOTUMEIF4E | |
| SCHEMBL5044961 | 0.86 | HTR2A (0.46) | GNRHRPIK3CDPIK3CACNR1HTR2A | |
| SCHEMBL6879620 | 0.85 | NOTUM (0.44) | NOTUMEIF4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6871844 | 0.85 | NOTUM (0.46) | NOTUMNPC1RAB9ASMN1; SMN2CNR1 | |
| SCHEMBL6884351 | 0.84 | MDM2 (0.46) | NOTUMEIF4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6871896 | 0.84 | NOTUM (0.43) | NOTUMEIF4EPIK3CANPC1RAB9A | |
| SCHEMBL6879796 | 0.84 | EIF4E (0.45) | NOTUMEIF4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6878789 | 0.83 | NOTUM (0.42) | NOTUMPIK3CANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040147572-A1 | Novel pyrrolyl-thiazole derivatives | HOFFMAN-LA ROCHE INC. | 2004-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147572-A1 | Novel pyrrolyl-thiazole derivatives | CNR1, CNR2, NPY1R | NOTUM 1360/4885EIF4E 2174/4885GNRHR 322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.