Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4E | P06730 | 3/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | TACR3 | P29371 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | CDC25A | P30304 | 1/20 | 0.39 |
| ▸ | CDC25B | P30305 | 1/20 | 0.39 |
| ▸ | CDC25C | P30307 | 1/20 | 0.39 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CPT1A | P50416 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6879732 | 0.88 | NOTUM (0.42) | EIF4ENOTUMPTGER4NPC1RAB9A | |
| SCHEMBL5043491 | 0.88 | EIF4E (0.43) | EIF4ENOTUMKDM4ENPC1RAB9A | |
| SCHEMBL6877134 | 0.87 | ALDH1A1 (0.48) | EIF4ENOTUMCDC25ACDC25BCDC25C | |
| SCHEMBL5049131 | 0.86 | HTR2A (0.44) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5039301 | 0.85 | CDC25A (0.49) | EIF4ENOTUMCDC25ACDC25BCDC25C | |
| SCHEMBL6881410 | 0.84 | EIF4E (0.49) | EIF4ECYP19A1CDC25ACDC25BCDC25C | |
| SCHEMBL6881069 | 0.84 | CYP1A1 (0.44) | EIF4ENOTUMCDC25ACDC25BCDC25C | |
| SCHEMBL6872874 | 0.83 | NOTUM (0.42) | EIF4ENOTUMTACR3CPT1A | |
| SCHEMBL6879620 | 0.83 | NOTUM (0.44) | EIF4ENOTUMCDC25ACDC25BCDC25C | |
| SCHEMBL6871844 | 0.82 | NOTUM (0.46) | NOTUMKDM4ENPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040147572-A1 | Novel pyrrolyl-thiazole derivatives | HOFFMAN-LA ROCHE INC. | 2004-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147572-A1 | Novel pyrrolyl-thiazole derivatives | CNR1, CNR2, NPY1R | EIF4E 2174/4885NOTUM 1360/4885TACR3 100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.