Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | PLK1 | P53350 | 1/20 | 0.49 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6879783 | 1.00 | HTT (0.49) | HTTALOX15PLK1DOT1LNPC1 | |
| SCHEMBL6879793 | 1.00 | HTT (0.49) | HTTALOX15PLK1DOT1LNPC1 | |
| SCHEMBL6881652 | 0.88 | ALDH1A1 (0.47) | HTTALOX15PLK1RAB9AALDH1A1 | |
| SCHEMBL6881648 | 0.88 | ALDH1A1 (0.47) | HTTALOX15PLK1RAB9AALDH1A1 | |
| SCHEMBL6881645 | 0.88 | ALDH1A1 (0.47) | HTTALOX15PLK1RAB9AALDH1A1 | |
| SCHEMBL6850592 | 0.81 | HTT (0.51) | HTTALOX15PLK1DOT1LNPC1 | |
| SCHEMBL6850587 | 0.81 | HTT (0.51) | HTTALOX15PLK1DOT1LNPC1 | |
| SCHEMBL6879090 | 0.81 | KMT2A (0.44) | HTTNPC1POLBRAB9AALDH1A1 | |
| SCHEMBL6852224 | 0.81 | KMT2A (0.44) | HTTNPC1POLBRAB9AALDH1A1 | |
| SCHEMBL6852222 | 0.81 | KMT2A (0.44) | HTTNPC1POLBRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |