Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 11/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 9/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6879817 | 1.00 | MCHR1 (0.46) | MCHR1ADRA2ARXFP1LMNAKDM4E | |
| SCHEMBL6872998 | 0.84 | MCHR1 (0.51) | MCHR1ADRA2ALMNAKDM4ESMN1; SMN2 | |
| SCHEMBL6872993 | 0.84 | MCHR1 (0.51) | MCHR1ADRA2ALMNAKDM4ESMN1; SMN2 | |
| SCHEMBL13792721 | 0.83 | MCHR1 (0.56) | MCHR1ADRA2AHTR1AADRA1AHRH1 | |
| SCHEMBL27652763 | 0.82 | KMT2A (0.50) | MCHR1ADRA2ARXFP1KDM4ESMN1; SMN2 | |
| SCHEMBL6874583 | 0.81 | LMNA (0.52) | MCHR1ADRA2ARXFP1LMNAKDM4E | |
| SCHEMBL6874577 | 0.81 | LMNA (0.52) | MCHR1ADRA2ARXFP1LMNAKDM4E | |
| SCHEMBL6867900 | 0.80 | MCHR1 (0.51) | MCHR1ADRA2ALMNAKDM4ESMN1; SMN2 | |
| SCHEMBL6867894 | 0.80 | MCHR1 (0.51) | MCHR1ADRA2ALMNAKDM4ESMN1; SMN2 | |
| SCHEMBL6875397 | 0.80 | LMNA (0.52) | MCHR1ADRA2ALMNAKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |