Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 11/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13792943 | 0.85 | MCHR1 (0.55) | KMT2AMAPTMEN1SMN1; SMN2PTGDR2 | |
| SCHEMBL6875404 | 0.85 | LMNA (0.52) | KMT2AMEN1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6875397 | 0.85 | LMNA (0.52) | KMT2AMEN1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6879817 | 0.82 | MCHR1 (0.46) | SMN1; SMN2KDM4EMCHR1ADRA2APPARG | |
| SCHEMBL6879814 | 0.82 | MCHR1 (0.46) | SMN1; SMN2KDM4EMCHR1ADRA2APPARG | |
| SCHEMBL6872998 | 0.80 | MCHR1 (0.51) | SMN1; SMN2KDM4EMCHR1ADRA2A | |
| SCHEMBL6872993 | 0.80 | MCHR1 (0.51) | SMN1; SMN2KDM4EMCHR1ADRA2A | |
| SCHEMBL13794836 | 0.80 | MCHR1 (0.56) | KMT2AMAPTMEN1SMN1; SMN2PTGDR2 | |
| SCHEMBL6457223 | 0.79 | KMT2A (0.52) | KMT2AMAPTMEN1SMN1; SMN2PTGDR2 | |
| SCHEMBL6457220 | 0.79 | KMT2A (0.52) | KMT2AMAPTMEN1SMN1; SMN2PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100451004-C | Pyrimidine derivatives | ARENA PHARM INC (JP) | 2009-01-14 | — | — | CN | disclosed |
| CN-1798736-A | Novel quinoline, tetrahydroquinazoline and pyrimidine derivatives and methods of treatment related to their use | ARENA PHARM INC (JP) | 2006-07-05 | — | — | CN | disclosed |