Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.69 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.69 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.69 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6884651 | 0.86 | PTGS1 (0.67) | PTGS1AKR1C3AKR1C2HDAC8MEN1 | |
| SCHEMBL10684986 | 0.84 | HTT (0.76) | HDAC8MEN1KMT2AKDM4ECYP1A2 | |
| SCHEMBL11278088 | 0.84 | PTGS1 (0.65) | PTGS1AKR1C3AKR1C2HDAC8MEN1 | |
| SCHEMBL1448732 | 0.83 | PTGS1 (0.73) | PTGS1AKR1C3AKR1C2MEN1KMT2A | |
| SCHEMBL11022943 | 0.82 | HDAC1 (0.65) | HDAC8MEN1KMT2ASMN1; SMN2RAB9A | |
| Methane SCHEMBL9087821 | 0.82 | PTGS1 (0.71) | PTGS1AKR1C3AKR1C2MEN1KMT2A | |
| SCHEMBL10587711 | 0.82 | PTGS1 (0.70) | PTGS1AKR1C3AKR1C2MEN1KMT2A | |
| SCHEMBL6885712 | 0.82 | PTGS1 (0.61) | PTGS1AKR1C3AKR1C2HDAC8MEN1 | |
| SCHEMBL6885747 | 0.82 | PTGS1 (0.61) | PTGS1AKR1C3AKR1C2HDAC8MEN1 | |
| 6-Methoxy-2-Naphthylacetic Acid SCHEMBL253759 | 0.81 | AKR1C3 (1.00) | PTGS1AKR1C3AKR1C2KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6730701-B2 | 6-METHOXY-2-NAPHTHYLACETIC ACID DERIVATIVE AS A PRODRUGS, USEFUL FOR TREATMENT OF INFLAMMATION IN HUMANS | NOBEX CORPORATION | 2004-05-04 | — | — | US | disclosed |
| EP-1335718-A1 | 6-METHOXY-2-NAPHTHYLACETIC ACID PRODRUGS | Nobex Corporation (US) | 2003-08-20 | — | — | EP | disclosed |
| US-6552078-B2 | Antiinflammatory and antiarthritic agents; rheumatic diseases; side effect reduction; ulcer and allergy resistance; non-irritating; easily hydrolyzed and solubilized; bioavailability | BIOCON LIMITED (IN) | 2003-04-22 | — | — | US | disclosed |
| WO-2002034260-A1 | 6-METHOXY-2-NAPHTHYLACETIC ACID PRODRUGS | NOBEX CORPORATION (US) | 2002-05-02 | — | — | WO | disclosed |
| US-20020028845-A1 | 6-methoxy-2-naphthylacetic acid prodrugs | BIOCON LIMITED (IN) | 2002-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020028845-A1 | 6-methoxy-2-naphthylacetic acid prodrugs | IL6, CYP2A6, TLR6 | PTGS1 648/4885AKR1C3 64/4885AKR1C2 179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.