SCHEMBL6880320

SCHEMBL6880320

c1ccc(Nn2cc3cncnc3n2)cc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 3/20 0.37
CYP1A2 P05177 6/20 0.33
CYP2C19 P33261 6/20 0.33
CYP3A4 P08684 5/20 0.33
CYP2D6 P10635 5/20 0.33
TSHR P16473 2/20 0.33
ALDH1A1 P00352 3/20 0.32
MAPT P10636 1/20 0.32
CYP2C9 P11712 1/20 0.32
ATM Q13315 1/20 0.32
HSD17B10 Q99714 4/20 0.31
ALOX15 P16050 3/20 0.31
CLK4 Q9HAZ1 2/20 0.31
LMNA P02545 1/20 0.31
MEN1 O00255 1/20 0.31
USP2 O75604 1/20 0.31
KMT2A Q03164 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
IMPDH2 P12268 1/20 0.31
PLK1 P53350 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7479332 0.69 ADORA3 (0.46) CYP1A2CYP2C19CYP3A4CYP2D6TSHR
SCHEMBL21676523 0.69 ADORA1 (0.34) EGFRALDH1A1MAPT
SCHEMBL6880333 0.67 EGFR (0.38) EGFRCYP1A2CYP2C19CYP3A4CYP2D6
SCHEMBL1128922 0.66 EGFR (0.34) EGFRPIK3CG
SCHEMBL309958 0.65 EGFR (0.33) EGFRPIK3CG
SCHEMBL5705720 0.65 EGFR (0.33) EGFR
SCHEMBL10441379 0.65 EGFR (0.33) EGFR
SCHEMBL29742185 0.65 KDM4E (0.53) EGFRCYP1A2CYP2C19CYP3A4CYP2D6
SCHEMBL4404749 0.62 CYP1A2 (0.40) EGFRCYP1A2CYP2C19CYP3A4CYP2D6
SCHEMBL4914126 0.62 CYP1A2 (0.35) CYP1A2CYP2C19CYP3A4CYP2D6TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0832091-B1 C-4' MODIFIED ADENOSINE KINASE INHIBITORS GENSIA SICOR INC (US) 2004-01-14 EP disclosed
EP-0832091-A1 C-4' MODIFIED ADENOSINE KINASE INHIBITORS GENSIA, INC. (US) 1998-04-01 EP disclosed
EP-0682519-A4 ADENOSINE KINASE INHIBITORS. GENSIA INC (US) 1997-12-17 EP disclosed
WO-1996040705-A1 C-4' MODIFIED ADENOSINE KINASE INHIBITORS GENSIA SICOR (US) 1996-12-19 WO disclosed
EP-0682519-A1 ADENOSINE KINASE INHIBITORS GENSIA, INC. (US) 1995-11-22 EP disclosed
WO-1994017803-A9 ADENOSINE KINASE INHIBITORS 1994-09-29 WO disclosed
WO-1994017803-A1 ADENOSINE KINASE INHIBITORS GENSIA, INC. (US) 1994-08-18 WO disclosed