Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 14/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 9/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.40 |
| ▸ | USP2 | O75604 | 10/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 9/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 7/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.37 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.36 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | CASP1 | P29466 | 3/20 | 0.34 |
| ▸ | CASP7 | P55210 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | HBB | P68871 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1682736 | 0.69 | TET2 (0.41) | CYP1A2ALDH1A1HSD17B10TET2TET1 | |
| SCHEMBL10926416 | 0.67 | ALDH1A1 (0.42) | CYP1A2CYP3A4CYP2C9ALDH1A1HSD17B10 | |
| SCHEMBL8801410 | 0.67 | MKNK2 (0.59) | CYP1A2CYP3A4CYP2C9ALDH1A1HSD17B10 | |
| SCHEMBL6664459 | 0.67 | HDAC6 (0.58) | ALDH1A1FGFR1HDAC6HTT | |
| SCHEMBL30099082 | 0.67 | MKNK2 (0.59) | CYP1A2CYP3A4CYP2C9ALDH1A1HSD17B10 | |
| SCHEMBL10059381 | 0.65 | ALDH1A1 (0.39) | CYP1A2CYP3A4CYP2C9ALDH1A1HSD17B10 | |
| SCHEMBL16474747 | 0.65 | ALDH1A1 (0.55) | CYP1A2CYP3A4ALDH1A1HSD17B10MAPK1 | |
| SCHEMBL4796775 | 0.64 | CDK4 (0.56) | CYP1A2CYP3A4CYP2C9ALDH1A1HSD17B10 | |
| SCHEMBL30099032 | 0.64 | CDK4 (0.56) | CYP1A2CYP3A4CYP2C9ALDH1A1HSD17B10 | |
| SCHEMBL1963855 | 0.63 | HSD17B10 (0.52) | CYP1A2CYP3A4CYP2C9ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549651-B1 | PYRIMIDOPYRIMIDONES AS KINASE INHIBITORS | WARNER LAMBERT CO (US) | 2009-12-23 | — | — | EP | disclosed |
| US-7196090-B2 | Kinase inhibitors | WARNER-LAMBERT COMPANY (US) | 2007-03-27 | — | — | US | disclosed |
| WO-2006038112-A1 | USE OF KINASE INHIBITORS TO PROMOTE NEOCHONDROGENESIS | WARNER-LAMBERT COMPANY LLC (US) | 2006-04-13 | — | — | WO | disclosed |
| EP-1549651-A1 | KINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011465-A1 | KINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-05 | — | — | WO | disclosed |
| US-20040019210-A1 | Kinase inhibitors | CHIVIKAS CONNOLLY CLEO J (US) | 2004-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040019210-A1 | Kinase inhibitors | CDK2, CDK1, CDK4 | CYP1A2 1331/4885CYP3A4 2224/4885CYP2C9 1920/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.