Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 11/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6880734 | 1.00 | NOTUM (0.51) | NOTUMKDM4EALDH1A1LMNATLR8 | |
| SCHEMBL6880729 | 1.00 | NOTUM (0.51) | NOTUMKDM4EALDH1A1LMNATLR8 | |
| SCHEMBL27594345 | 0.81 | NOTUM (0.54) | NOTUMKDM4EALDH1A1LMNATLR8 | |
| SCHEMBL6876954 | 0.76 | LTA4H (0.42) | — | |
| SCHEMBL6854128 | 0.76 | LTA4H (0.42) | — | |
| SCHEMBL6876949 | 0.76 | LTA4H (0.42) | — | |
| SCHEMBL6852304 | 0.75 | NOTUM (0.50) | NOTUMKDM4EALDH1A1LMNATLR8 | |
| SCHEMBL6852297 | 0.75 | NOTUM (0.50) | NOTUMKDM4EALDH1A1LMNATLR8 | |
| SCHEMBL17694561 | 0.74 | NOTUM (0.78) | NOTUMKDM4EALDH1A1LMNATLR8 | |
| SCHEMBL6879785 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |