Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6880794 | 1.00 | PKM (0.45) | PKMLMNAALDH1A1MAPTKDM4E | |
| SCHEMBL6875875 | 0.89 | EPHX2 (0.45) | ALDH1A1MCHR1ADRA2ATP53CYP2D6 | |
| SCHEMBL6875871 | 0.89 | EPHX2 (0.45) | ALDH1A1MCHR1ADRA2ATP53CYP2D6 | |
| SCHEMBL6877751 | 0.88 | MCHR1 (0.46) | LMNAALDH1A1KDM4EMCHR1ADRA2A | |
| SCHEMBL6877748 | 0.88 | MCHR1 (0.46) | LMNAALDH1A1KDM4EMCHR1ADRA2A | |
| SCHEMBL6460838 | 0.88 | MEN1 (0.40) | PKMALDH1A1MAPTMCHR1ADRA2A | |
| SCHEMBL6460846 | 0.88 | MEN1 (0.40) | PKMALDH1A1MAPTMCHR1ADRA2A | |
| SCHEMBL6463916 | 0.88 | MCHR1 (0.41) | LMNAALDH1A1MCHR1ADRA2A | |
| SCHEMBL6463929 | 0.88 | MCHR1 (0.41) | LMNAALDH1A1MCHR1ADRA2A | |
| SCHEMBL6866519 | 0.88 | GAA (0.45) | LMNAALDH1A1MAPTKDM4EMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |