Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 8/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6875875 | 1.00 | EPHX2 (0.45) | EPHX2MCHR1ADRA2ATP53GAA | |
| SCHEMBL6874530 | 0.92 | EPHX2 (0.56) | EPHX2MCHR1ADRA2ATP53GAA | |
| SCHEMBL6874535 | 0.92 | EPHX2 (0.56) | EPHX2MCHR1ADRA2ATP53GAA | |
| SCHEMBL6876347 | 0.92 | P2RY1 (0.44) | MCHR1ADRA2AADRA1AHRH1HTR2B | |
| SCHEMBL6876354 | 0.92 | P2RY1 (0.44) | MCHR1ADRA2AADRA1AHRH1HTR2B | |
| SCHEMBL6876806 | 0.90 | MCHR1 (0.47) | EPHX2MCHR1ADRA2ATP53ALDH1A1 | |
| SCHEMBL6876812 | 0.90 | MCHR1 (0.47) | EPHX2MCHR1ADRA2ATP53ALDH1A1 | |
| SCHEMBL6880790 | 0.89 | PKM (0.45) | MCHR1ADRA2ATP53ALDH1A1CYP2D6 | |
| SCHEMBL6880794 | 0.89 | PKM (0.45) | MCHR1ADRA2ATP53ALDH1A1CYP2D6 | |
| SCHEMBL6869037 | 0.88 | KMT2A (0.52) | EPHX2MCHR1ADRA2ATP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |