Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | KLK7 | P49862 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6880943 | 1.00 | ADRA2A (0.47) | ADRA2AMCHR1SIGMAR1KLK7MAPT | |
| SCHEMBL6880135 | 0.92 | SIGMAR1 (0.52) | ADRA2AMCHR1SIGMAR1MAPTRAB9A | |
| SCHEMBL6880141 | 0.92 | SIGMAR1 (0.52) | ADRA2AMCHR1SIGMAR1MAPTRAB9A | |
| SCHEMBL6874876 | 0.90 | MCHR1 (0.43) | ADRA2AMCHR1KLK7KDM4ELMNA | |
| SCHEMBL6874884 | 0.90 | MCHR1 (0.43) | ADRA2AMCHR1KLK7KDM4ELMNA | |
| SCHEMBL6880627 | 0.88 | RXFP1 (0.49) | ADRA2AMCHR1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL6880619 | 0.88 | RXFP1 (0.49) | ADRA2AMCHR1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL6466405 | 0.88 | MCHR1 (0.46) | ADRA2AMCHR1MAPTKDM4ELMNA | |
| SCHEMBL6880443 | 0.88 | KDR (0.51) | ADRA2AMCHR1MAPTRAB9AKDM4E | |
| SCHEMBL6880440 | 0.88 | KDR (0.51) | ADRA2AMCHR1MAPTRAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |