Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 19/20 | 0.58 |
| ▸ | ITGA4 | P13612 | 19/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL686731 | 0.90 | MAPT (0.55) | ITGB1ITGA4RAB9A | |
| SCHEMBL687571 | 0.90 | ALDH1A1 (0.50) | ITGB1ITGA4 | |
| SCHEMBL688325 | 0.88 | ALDH1A1 (0.51) | ITGB1ITGA4 | |
| SCHEMBL695420 | 0.88 | MAPT (0.54) | ITGB1ITGA4 | |
| SCHEMBL688223 | 0.86 | PTGER3 (0.55) | RAB9A | |
| SCHEMBL4700630 | 0.85 | MAPT (0.44) | ITGB1ITGA4 | |
| SCHEMBL686838 | 0.85 | PTGER3 (0.51) | RAB9A | |
| SCHEMBL687428 | 0.85 | PTGER3 (0.56) | RAB9A | |
| SCHEMBL688073 | 0.85 | ALDH1A1 (0.44) | ITGB1ITGA4 | |
| SCHEMBL687886 | 0.85 | PTGER3 (0.56) | RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1176956-B1 | CARBOXYLIC ACID DERIVATIVES THAT INHIBIT THE BINDING OF INTEGRINS TO THEIR RECEPTORS | ENCYSIVE PHARMACEUTICALS INC (US) | 2008-01-09 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |