Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 4/20 | 0.46 |
| ▸ | THRB | P10828 | 4/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9053303 | 0.87 | HTT (0.44) | ALOX5HTTPOLBMEN1LMNA | |
| SCHEMBL9015990 | 0.84 | HTT (0.44) | ALOX5HTTPOLBMEN1LMNA | |
| SCHEMBL7096822 | 0.82 | HTT (0.45) | HTTPOLBMEN1LMNAADRA2A | |
| SCHEMBL19295731 | 0.78 | THRA (0.42) | THRATHRBESR1LMNACYP3A4 | |
| SCHEMBL2910532 | 0.77 | POLB (0.62) | HTTPOLBMAPTKMT2AALDH1A1 | |
| Hx-1171 SCHEMBL29375871 | 0.76 | ESR1 (0.50) | THRATHRBALOX5ESR1 | |
| Hx-1171 SCHEMBL688955 | 0.76 | ESR1 (0.50) | THRATHRBALOX5ESR1 | |
| SCHEMBL10618373 | 0.75 | THRA (0.53) | THRATHRBALOX5HTTESR1 | |
| SCHEMBL6741473 | 0.75 | SMPD1 (0.46) | ALOX5MEN1NR1I2LMNACHRM2 | |
| SCHEMBL8600805 | 0.75 | HTT (0.44) | HTTPOLBADRA2AMAPTOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2052719-B1 | Curative drug for neurodegenerative diseases | NIPPON HYPOX LAB INC (JP) | 2013-01-16 | — | — | EP | claimed |
| EP-2110127-B1 | Hepatic Fibrosis Inhibitor | NIPPON HYPOX LAB INC (JP) | 2012-02-29 | — | — | EP | claimed |
| US-7847132-B2 | Hepatic fibrosis inhibitor | NIPPON HYPOX LABORATORIES INCORPORATED (JP) | 2010-12-07 | — | — | US | claimed |
| US-20100184858-A1 | Hepatic fibrosis inhibitor | BIOTOXTECH CO., LTD (KR) | 2010-07-22 | — | — | US | claimed |
| US-20100160432-A1 | Curative drug for neurodegenerative diseases | SUGIYAMA SATORU | 2010-06-24 | — | — | US | claimed |
| US-20090270654-A1 | HEPATIC FIBROSIS INHIBITOR | NIPPON HYPOX LABORATORIES INCORPORATED (JP) | 2009-10-29 | — | — | US | claimed |
| EP-2110127-A1 | Hepatic Fibrosis Inhibitor | NIPPON HYPOX LABORATORIES INCORPORATED (JP) | 2009-10-21 | — | — | EP | claimed |
| EP-2052719-A1 | Curative drug for neurodegenerative diseases | NIPPON HYPOX LABORATORIES INCORPORATED (JP) | 2009-04-29 | — | — | EP | claimed |
| US-20090105339-A1 | Curative drug for neurodegenerative diseases | NIPPON HYPOX LABORATORIES INCORPORATED (JP) | 2009-04-23 | — | — | US | claimed |
| EP-2052719-B1 | Curative drug for neurodegenerative diseases | NIPPON HYPOX LAB INC (JP) | 2013-01-16 | — | — | EP | disclosed |
| EP-2110127-B1 | Hepatic Fibrosis Inhibitor | NIPPON HYPOX LAB INC (JP) | 2012-02-29 | — | — | EP | disclosed |
| US-7847132-B2 | Hepatic fibrosis inhibitor | NIPPON HYPOX LABORATORIES INCORPORATED (JP) | 2010-12-07 | — | — | US | disclosed |
| US-20100184858-A1 | Hepatic fibrosis inhibitor | BIOTOXTECH CO., LTD (KR) | 2010-07-22 | — | — | US | disclosed |
| US-20100160432-A1 | Curative drug for neurodegenerative diseases | SUGIYAMA SATORU | 2010-06-24 | — | — | US | disclosed |
| US-20090270654-A1 | HEPATIC FIBROSIS INHIBITOR | NIPPON HYPOX LABORATORIES INCORPORATED (JP) | 2009-10-29 | — | — | US | disclosed |
| EP-2110127-A1 | Hepatic Fibrosis Inhibitor | NIPPON HYPOX LABORATORIES INCORPORATED (JP) | 2009-10-21 | — | — | EP | disclosed |
| EP-2052719-A1 | Curative drug for neurodegenerative diseases | NIPPON HYPOX LABORATORIES INCORPORATED (JP) | 2009-04-29 | — | — | EP | disclosed |
| US-20090105339-A1 | Curative drug for neurodegenerative diseases | NIPPON HYPOX LABORATORIES INCORPORATED (JP) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100184858-A1 | Hepatic fibrosis inhibitor | HDGF, HAVCR2, FABP1 | THRA 3624/4885THRB 3151/4885ALOX5 1889/4885 |
| US-20090105339-A1 | Curative drug for neurodegenerative diseases | HTT, SNCA, NQO1 | THRA 4644/4885THRB 4500/4885ALOX5 1284/4885 |
| US-20100160432-A1 | Curative drug for neurodegenerative diseases | HTT, SNCA, NQO1 | THRA 4644/4885THRB 4500/4885ALOX5 1284/4885 |
| US-20090270654-A1 | HEPATIC FIBROSIS INHIBITOR | HDGF, HAVCR2, FABP1 | THRA 3624/4885THRB 3151/4885ALOX5 1889/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.