Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | DAGLA | Q9Y4D2 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6881237 | 1.00 | MCHR1 (0.46) | MCHR1ADRA2AEPHX2EPHX1SIGMAR1 | |
| SCHEMBL6872664 | 0.85 | MCHR1 (0.43) | MCHR1ADRA2ALMNAMEN1KMT2A | |
| SCHEMBL6872666 | 0.85 | MCHR1 (0.43) | MCHR1ADRA2ALMNAMEN1KMT2A | |
| SCHEMBL6875056 | 0.85 | MCHR1 (0.49) | MCHR1ADRA2AEPHX2EPHX1LMNA | |
| SCHEMBL6875053 | 0.85 | MCHR1 (0.49) | MCHR1ADRA2AEPHX2EPHX1LMNA | |
| SCHEMBL13794629 | 0.84 | MCHR1 (0.63) | MCHR1ADRA2AEPHX2SIGMAR1POLB | |
| SCHEMBL6877314 | 0.84 | MCHR1 (0.47) | MCHR1ADRA2AEPHX1SIGMAR1MEN1 | |
| SCHEMBL6458281 | 0.84 | MCHR1 (0.59) | MCHR1ADRA2AMEN1KMT2A | |
| SCHEMBL6458289 | 0.84 | MCHR1 (0.59) | MCHR1ADRA2AMEN1KMT2A | |
| SCHEMBL6873170 | 0.83 | MCHR1 (0.43) | MCHR1ADRA2ALMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |